Iron Deficiency and Pregnancy

Iron deficiency and iron deficiency anemia are significant health problems worldwide, especially for women of reproductive age and during pregnancy. These issues are more common in low-income countries, but they are also prevalent in developed nations.

Iron Deficiency in Pregnancy

  • Increased Iron Requirements: Pregnancy increases the body’s demand for iron due to expanded blood volume and the nutrient required for the growth and development of the foetus.
  • Potential Outcomes: Iron deficiency during pregnancy is linked to adverse effects, such as low birth weight, prematurity, intrauterine growth restriction, and increased maternal illness.
  • Foetal Impact: The developing foetal brain is at risk due to maternal iron deficiency, which can lead to cognitive, social-emotional, and adaptive function issues in the offspring.

Common Signs and Symptoms

  • Fatigue, Weakness, Dizziness: These symptoms are due to lowered oxygen delivery to the tissues.
  • Pale Skin: Low haemoglobin levels can result in pale or yellowish skin.
  • Pica: A craving for non-food substances like ice is a sign of severe iron deficiency.
  • Others: Headaches, palpitations, hair loss, and tinnitus (ringing sound in ear) can also occur.

Prevention and Treatment

  • Iron Supplements: Iron supplements in the form of tablets, capsules, syrup, or drops are commonly used to prevent and treat iron deficiency anemia during pregnancy.
  • Dietary Sources: Lean meats, poultry, and fish provide more bioavailable iron compared to plant-based sources like cereals, legumes, and dark green leafy vegetables.
  • Considerations for Vegetarians and Vegans: Those on plant-based diets should take care to include sources of vitamin C, which enhances non-heme (veg) iron absorption, in their diets.

High-Risk Factors

  • Close Pregnancies: Women who become pregnant soon after a previous pregnancy are at higher risk for iron deficiency.
  • Multiple Pregnancies: Women carrying multiple children (e.g., twins) have higher iron demands.
  • Frequent Vomiting: Morning sickness and other forms of vomiting can deplete iron stores.
  • Heavy Bleeding: A history of heavy menstrual bleeding increases the risk of iron deficiency.

Global Prevalence of Iron Deficiency and Anemia

  • Iron deficiency and anemia are common globally, especially in low-income countries and developing regions.
  • Anemia affects around one-third of non-pregnant women worldwide, with higher prevalence in pregnant women (37% globally and over 50% in India).
  • Even in developed countries, many women of reproductive age may have low iron stores, putting them at risk of anemia during pregnancy.

Recommendations

  • Routine Iron Supplementation: Routine iron supplementation is recommended during pregnancy to support the mother’s and baby’s health.
  • Regular Monitoring: Pregnant women should have their haemoglobin levels monitored regularly to ensure adequate iron levels.
  • Nutritional Guidance: Health care providers can offer nutritional guidance to ensure pregnant women consume enough iron-rich foods and consider supplements if necessary.
  • Careful management: Special care and management is required during Pregnancy to ensure the health and well-being of both the mother and the baby.

Cochrane Database Syst Rev. 2016; 2016(4): CD009747.

Am J Obstet Gynecol. 2020; 223(4): 516–524.

Saudi Med J. 2015; 36(2): 146–149.

Obstetrics & Gynecology 2021; 138(4): 663-674. 

WHO Global Anaemia estimates, 2021 Edition

American Society of Hematology

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